Logo Università degli Studi di Milano


Department of

 
 
News  

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription

Issued in Nature Communications the work by Prof. Stefano Biffo of the Department of Biosciences

"eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription".

Since long, transcriptional control of lipogenesis has been the leading model. Here we show that eIF6, a translation factor, is rate-limiting for the protein synthesis of lipogenic transcription factors, thus showing that lipid metabolism is controlled at the level of translation.

Link: http://www.nature.com/ncomms/2015/150918/ncomms9261/full/ncomms9261.html

 

18 September 2015
Back to top