Our research is mainly focused to biomarkers of oxidative stress/damage, especially oxidative protein modifications, identified by redox proteomics and mass spectrometry techniques and redox alterations of glutathione and related low molecular mass thiols, in different biological systems: primary human cultured cells, immortalized human cell lines, erythrocytes, blood and plasma.

 

 Isabella Dalle Donne

Associate Professor in Comparative Anatomy and Cytology


Email: isabella.dalledonne@unimi.it

Address: VI floor / tower B

Thesis available: >>>

External links:ResearchGate

Keywords: oxidative stress, biomarkers, redox proteomics, carbonylated proteins, S-glutathionylated proteins

Main topics of the group:

• Protein carbonylation in inflammatory pathologies and cellular models.
• Protein S-glutathionylation in cellular models.
• Cellular and molecular aspects of oxidative damage induced by cigarette smoke.
• Glutathione/glutathione disulphide ratio and cellular redox state.
• Plasma redox state in end stage renal disease.

 

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Aldo Milzani

Associate Professor in Comparative Anatomy and Cytology


Email: aldo.milzani@unimi.it

Address: VI floor / tower B

Thesis available: >>>

External links:PubMed

Keywords: oxidative stress, glutathione, antioxidants, protein thiolation, cellular redox status

Main topics of the group:

• Oral sucrosomial versus intravenous iron supplementation for the treatment of anaemia in haemodialyzed patients.
• Effects of natural and synthetic antioxidants on intra-/extracellular redox status.
• Protein S-thiolation.
• Proteome alterations in the tendons of children and adolescents afflicted by cerebral palsy-induced spasticity.

 

 Graziano Colombo

Assistant Professor in Comparative Anatomy and Cytology


Email: graziano.colombo@unimi.it

Address: VI floor / tower B

Thesis available: >>>

External links:ResearchGate

Keywords: Redox proteomics, thiols, carbonyl, cigarette smoke, haemodialyzed patients

Main topics of the group:

• Cell biology of cigarette smoke-induced oxidative damage.
• Plasma biomarkers of oxidative stress and inflammation in haemodialyzed patients.
• Characterization of advanced oxidation products of human plasma proteins.
• Determination and quantification of the intracellular and extracellular thiol proteome.
• Biomarkers of oxidative stress in avian reproduction.