STRUCTURAL BIOLOGY

We study the 3D structure of proteins ranging from bacterial antigens, viral enzymes and transcription factors to proteins involved in apoptosis and amyloidosis, through X-ray crystallography, biochemical, biophysical and computational approaches. We focus on structure-function relationships to develop small molecule inhibitors and vaccine components targeting specific pathologies.

Website: http://users.unimi.it/biolstru/Home.html

Marco Nardini

Full Professor in Biochemistry

Email: marco.nardini@unimi.it

Phones: +39 02 503 14893

Address: V floor / tower C

Website: >>>

Thesis available: >>>

External links:PubMed GoogleScholar

Keywords: Structural Biology, X-ray crystallography

Main topics of the group: - 3D structure determination and analysis of transcription factors, enzymes and their complexes with other proteins, DNA, substrates and/or inhibitors.

Stefano Ricagno

Associate Professor in Biochemistry

Email: stefano.ricagno@unimi.it

Phones: +39 02 503 14914

Address: V floor / tower B

Website: >>>

Thesis available: >>>

External links:PubMed ResearchGate ORCID

Keywords: amyloid aggregation and misfolding, amyloidosis, proteotoxicity, protein structure, protein conformational stability

Main topics of the group: Structural and biophysical characterization of aggregation-prone proteins, biochemical studies of proteotoxicity in neurodegeneration and in systemic amyloidosis.

Louise Gourlay

Assistant Professor in Biochemistry

Email: louise.gourlay@unimi.it

Phones: +39 02 503 14919

Address: V floor / tower B

Website: >>>

Thesis available: >>>

External links:PubMed Scopus ORCID altro

Keywords: Structure-based antigen design, bacterial protein antigens, X-ray crystallography, epitope design

Main topics of the group: - My studies regard 3D structure-based antigen design of protein antigens from bacterial pathogens and human parasites for the development of new vaccines and diagnostic tools.

Other:http://users.unimi.it/biolstru/gourlay-lab.html

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Eloise Mastrangelo

CNR Assistant Professor in Biochemistry

Email: eloise.mastrangelo@unimi.it

Phones: +39 02 503 14898

Address: V floor / tower C

Website: >>>

Thesis available: Ask the teacher

External links:ORCID

Keywords: apoptosis and cancer, viruses, structure-based drug design, protein-protein and protein-nucleotide interaction, enzyme activity

Main topics of the group: - Structural Biology, Molecular modeling, Drug discovery. We apply biophysical methods to analyze the structure of proteins involved in human pathologies such as viral infections and tumors. The protein structures are used for the identification/optimization of small molecules that inhibit protein biological functions. Some inhibitors can be developed as new drugs in the treatment of viral diseases and tumors.

https://bioscienzebio.unimi.it/video_docente/video1_Eloise-Mastrangelo.mp4

Mario Milani

CNR Assistant Professor in FIS/07- Biofisica

Email: mario.milani@unimi.it

Phones: +39 02 503 14767

Address: V floor / tower C

Thesis available: Ask the teacher

External links:GoogleScholar

Keywords: protein structure analysis; in silico docking; structure-based drug design; molecular dynamics simulations; biophysics

Main topics of the group: I study viral and bacterial proteins, proteins involved in cancer, in genetic or degenerative diseases to find new drugs

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